{"id":1192,"date":"2023-01-26T07:05:50","date_gmt":"2023-01-26T07:05:50","guid":{"rendered":"http:\/\/agderma.de\/?page_id=1192"},"modified":"2025-03-15T15:43:05","modified_gmt":"2025-03-15T15:43:05","slug":"dosing-aerosols-climate-relevant-therapy","status":"publish","type":"page","link":"https:\/\/agderma.de\/en\/themen\/dosieraerosole-klimarelevante-therapie\/","title":{"rendered":"Metered dose inhalers Climate-relevant therapy"},"content":{"rendered":"
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Metered dose inhalers Climate-relevant therapy<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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The therapy of asthma and COPD is climate-relevant<\/h3>

The majority of dermatologists are familiar with the diagnosis and treatment of allergic diseases of the upper respiratory tract such as rhinoconjunctivitis allergica and asthma. Seasonal shifts and prolongation of the pollen season caused by climate change have\u00a0Allergic respiratory diseases have increased sharply since the 1980s.<\/a>which affects the frequency of prescribing DAe and PI.<\/p>

Daily medication against allergic asthma is prescribed in two different forms of application, among others:<\/p>

  1. Metered dose inhalers (DAe)<\/strong> are applied to the mouth. By applying pressure to the trigger, a propellant with active ingredient is delivered into the respiratory tract with simultaneous inhalation.<\/li>
  2. Powder inhalers (PI)<\/strong> are enclosed by the mouth. Inhalation takes place by suction during rapid inhalation.<\/li><\/ol>

    Propellants of metered dose inhalers are more harmful to the climate than powder inhalers<\/h3>

    In addition to the greenhouse gas carbon dioxide, whose share has risen sharply since industrialisation, other greenhouse gases such as\u00a0Methane<\/a>nitrous oxide and man-made fluorinated greenhouse gases (F-gases) are released into the atmosphere. F-gases do not affect the ozone layer, unlike CFCs, whose production has been banned worldwide since 2020.<\/p>

    F-gases are not only found in products such as freezers, air conditioners, fire extinguishers and insulation materials, but also in asthma sprays. The\u00a0Global warming potential of these gases is about 100 to 23,000 times higher<\/a>\u00a0as that of carbon dioxide. The\u00a0Dwell time in the atmosphere<\/a>\u00a0is in some cases between a few decades and several hundred years. Worldwide, they contribute around\u00a0two per cent to the greenhouse effect<\/a>\u00a0and thus about as much as international air traffic. Previous research has shown, for example, that DAe prescribed in England contribute 3.9 % to the carbon footprint of the UK National Health Service. In Germany, F-gas emissions already accounted for\u00a0Federal Environment Agency<\/a>\u00a0accounts for about 1.6 per cent of greenhouse gas emissions.<\/p>

    The F-gases used in asthma sprays<\/a>mostly tetrafluoroethane HFA 134a and heptafluoropropane HFA 227ea, are powerful greenhouse gases and up to 1,430 and 3,220 times more potent than carbon dioxide respectively.<\/p>

    Comparison of metered dose inhalers (DAe) - powder inhalers (PI)<\/h3>

    If we now compare the carbon dioxide balance of DAe with PI, that of\u00a0PI up to 20 times better<\/a>\u00a0as\u00a0which DAe<\/a>.<\/p>

    Most of the active substances and combinations of active substances that play a role in the therapy of asthma and COPD are available both as DAe and PI.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    * In\u00a0Studies<\/a>\u00a0it was shown that the effectiveness of the respective systems DAe versus PI does not depend on the type of drug, but on the correct application.<\/p>

    ** cf. https:\/\/bmjopen.bmj.com\/content\/9\/10\/e028763<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    Recommendation for the prescription of asthma medication:<\/strong><\/p>